Patrón de hipoperfusión de ganglios basales y alteración frontal, en línea media, por compromiso de las áreas premotora y motora suplementaria. Preservación de ribete prefrontal. Demencia de desconexión. 
(PSP; Huntigton;  Buchpigel (REMN vol14; nº5; p 349): (n=4) Tres hipoperfusion definida en ambos lóbulos frontales; en general en todos cierta extension a cortex temporal y parietal. ?No anormalidad en tálamo, estriado o cerebelo. El cuarto hipoperfusion leve en zona frontal superior iqda. SPET papel en dif. de otros síndromes parkinsonianos. 

Ver Trabajos PET: hay varios. Dos subclases. 
 Arnold-G  
SO: J-Neural-Transm-Suppl. 1994; 42: 111-8 
AB: In order to in vivo identify subgroups in eight patients with the clinical diagnosis of progressive supranuclear palsy (PSP), we have performed 123I-iodobenzamide single photon emission computed tomography (IBZM-SPECT), a nuclear medicine technique, to visualize dopamine D2 receptors in vivo, and high resolution (TE/TR 2900/20-90) magnetic resonance imaging (MRI) to evaluate morphological CNS changes. All patients exhibited similar clinical featuresœ including supranuclear vertical gaze palsy, especially of downward gaze, predominantly axial rigidity especially in the neck, bradykinesia, instability of balance with easy falls, and poor response to dopaminergic drugs. Specific striatal dopamine D2 receptor binding in IBZM-SPECT, as calculated by a basal ganglia to frontal cortex ratio (BG/FC) was reduced in 5 patients, but normal in 3 œ patients. In MRI, ?these 3 patients exhibited multiple hyperintense white matter lesionsœ; 2 of them had no midbrain atrophy. In contrast, all 5 patients with reduced IBZM binding lacked multiple white matter lesions in MRI, but 4 of them showed marked midbrain atrophy.This pilot study with IBZM-SPECT for in vivo imaging of striatal dopamine D2 receptors and T2-weighted MRI supports published neuropathological findings that clinical signs of PSP appeared to be due to heterogeneous neuropathology.

AU: Kondo-S; SO: Rinsho-Shinkeigaku. 1994 Jun; 34(6):531-7. 
AB: We studied cerebral blood flow and oxygen metabolismœ in 6 patients with pure akinesia (PA), 8 patients with progressive supranuclear palsy (PSP), 16 patients with Parkinson's disease (PD), and 10 normal control subjects using positron emission tomography (PET). Regions of interest were studied in the cerebral cortex (the frontal, temporal, parietal, and occipital lobe), thalamus, cerebellar hemispheres, cerebellar vermis, and brainstem. 
- In patients with PA, regional cerebral blood flow (CBF) was significantly decreased in the frontal cortex, thalamus, and brainstemœ compared with normal control subjects. 
- PSP patients showed significantly decreased CBF in the entire cerebral cortex, thalamus, cerebellar hemispheres, and brainstemœ and regional cerebral oxygen metabolic rate (CMRO2) in the frontal cortex, thalamus, and brainstem, whereas patients with PD were revealed to be normal in both CBF and CMRO2 values. In conclusion, a part of patients with PA may be in the early stage of PSP or may be atypical presentations of PSP whose symptom is only akinesiaœ judging from the followings. 1) PET findings demonstrated a close similarity between PA and PSP; a pattern of CBF and CMRO2 decrement especially in the frontal cortex, thalamus and brainstem. 2) Patients with PA were shown to have similar pathological changes to PSP in recent studies. 3) Several authors reported that some PSP cases could show only akinesia initially, later developing dementia, supranuclear ophthalmoplegia, pseudobulbar palsy, and nuchal rigidity during their illnesses.